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The least-squares mean percentage change in body weight at 24 weeks in the retatrutide groups was −7.2% in the 1 mg group, and up to −17.5% in the 12 mg group, as compared with −1.6% in the placebo group

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In a head-to-head clinical trial comparing exenatide BID (Byetta®) and exenatide QW (Bydureon®), the incidence of nausea in patients treated with Byetta® was 35% compared to 14% in those treated with Bydureon® [119]